Patent · US Active

Polypeptide compositions comprising spacers

US11771718B2 · kind B2 · utility

2Cited by
3References
34Claims
0Family size

Assignee

Inventor

Key dates

Filing dateOct 17, 2018
Grant dateOct 3, 2023
Priority date—
Expiry dateMay 31, 2042

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N15/85
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Disclosed herein are methods and compositions including antigen-binding polypeptides comprising a stalk region and a stalk extension region. In some cases, the antigen-binding compositions comprising the stalk extension region has increased expression on a cell surface and, in some cases, has increased antigen-binding efficiency. A subject antigen binding polypeptide can be a chimeric antigen receptor (CAR).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.