Methods and compositions for treating microbial inflammation

US11771739B2 · kind B2 · utility

Assignees

• VANDERBILT UNIVERSITY · US
• THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS · US

Inventors

• Jack J. Hawiger · Sharon, US
• Jozef Zienkiewicz · Nashville, US
• Ruth Ann Veach · Brentwood, US
• Yan Liu · Nashville, US
• Lukasz S. Wylezinski · Nashville, US

Key dates

• Filing date: Jun 18, 2018
• Grant date: Oct 3, 2023
• Expiry date: Jun 18, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compositions and methods for treating microbial inflammation including its end-stage sepsis and conditions associated with the microbial inflammation such as thrombocytopenia and hypoglycogenemia. In one aspect, the compositions and methods disclosed herein can also be used to enhance clearance of microbes from infected tissues, organs, or systems in a subject. Also disclosed herein are compositions and methods for reducing levels of stress responsible transcription factors and metabolic transcription factors in a cell in a subject with microbial inflammation.