Self-asssembling nanostructure vaccines

US11771755B2 · kind B2 · utility

Assignee

• University of Washington · US

Inventors

• Neil P. KING · Seattle, US
• David Baker · Ann Arbor, US
• Lance Joseph STEWART · Bainbridge Island, US
• Brooke Fiala · Seattle, US
• Daniel ELLIS · Columbus, US
• Lauren Carter · Seattle, US
• Rashmi Ravichandran · Seattle, US
• George Ueda · Seattle, US
• Jorge Fallas · Seattle, US
• Una Nattermann · Seattle, US

Key dates

• Filing date: Feb 28, 2019
• Grant date: Oct 3, 2023
• Expiry date: Feb 28, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanostructures and nanostructure-based vaccines that display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens are provided. Some vaccines are useful for preventing or decreasing the severity of infection with an infectious agent, including, for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus, flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins, vaccine compositions, and methods of administration.