Patent · US Active

Naphthalenesulfonamide compound, preparation method, and application

US11773057B2 · kind B2 · utility

0Cited by

0References

7Claims

0Family size

Assignee

CHINA PHARMACEUTICAL UNIVERSITY · CN

Inventors

Qidong You · 安丰镇, CN
Zhengyu JIANG · Nanjing, CN
Yuting Liu · Tangxia, CN
Mengchen Lu · Nanjing, CN
Hongli Shao · 安丰镇, CN
Jing Zhao · Shanghai, CN
Xiaoli Xu · Shanghai, CN
Xiaoke GUO · 安丰镇, CN
Lei Wang · Shanghai, CN

Key dates

Filing date	Apr 13, 2020
Grant date	Oct 3, 2023
Priority date	—
Expiry date	Jun 26, 2040

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed in the present invention are a naphthalenesulfonamide compound, a preparation method, and an application. The naphthalenesulfonamide compound provided by the present invention can interfere with Keap1-Nrf2 binding and activate Nrf2 to relieve inflammatory damage and improve an inflammatory microenvironment, has a potential anti-inflammatory activity, and can be used for preparing an anti-inflammatory drug for inflammatory damage of various inflammation-related diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, intestinal Inflammations, rheumatoid arthritis, etc.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.