Heterocyclic g-protein-coupled receptor 52 (GPR52) agonists

US11773065B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Jia Zhou · Galveston, US
• John Arthur Allen · Galveston, US
• Pingyuan Wang · Shanghai, CN
• Daniel E. FELSING · Galveston, US

Key dates

• Filing date: Oct 12, 2021
• Grant date: Oct 3, 2023
• Expiry date: Oct 12, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Embodiments are directed to novel GPR52 activators. In particular, a series of novel 1-(pyrimidin-4-yl)indoline-4-carboxamide analogs that have been identified as potent and selective GPR52 agonists. The optimized GPR52 agonist that, for example, can be used as a valuable pharmacological tool or a drug candidate for investigating the physiological and therapeutic potential of GPR52 activation for various human diseases.