Methods of making high enantioselective secondary alcohols
US11773118B2 · kind B2 · utility
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Key dates
| Filing date | Feb 21, 2020 |
| Grant date | Oct 3, 2023 |
| Priority date | — |
| Expiry date | Sep 14, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/004
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The “R-form” compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity. After then, the “S-form” compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.