Patent · US Active

Generation of human spinal cord neural stem cells

US11773369B2 · kind B2 · utility

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8Claims

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Assignee

The Regents of the University of California · US

Inventors

Hiromi Kumamaru · Village of La Jolla, US
Mark H. Tuszynski · Village of La Jolla, US

Key dates

Filing date	Aug 2, 2019
Grant date	Oct 3, 2023
Priority date	—
Expiry date	Mar 29, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2533/90
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Spinal cord neural stem cells (NSCs) have great potential to reconstitute damaged spinal neural circuitry. In some embodiments, derivation of spinal cord NSCs from human pluripotent stem cells (hPSCs) is described. These spinal cord NSCs can differentiate into a diverse population of spinal cord neurons comprising multiple positions in the dorso-ventral axis, and can be maintained for prolonged time periods. After grafting into injured spinal cords, grafts may be rich with excitatory neurons, extend large numbers of axons over long distances, innervate their target structures, and enable robust corticospinal regeneration. In some embodiments, hPSC-derived spinal cord NSCs enable a broad range of biomedical applications for in vitro disease modeling, and can provide a clinically-translatable cell source for spinal cord “replacement” strategies in several spinal cord disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.