Patent · US Active

Repairing compound heterozygous recessive mutations by allele exchange

US11773410B2 · kind B2 · utility

0Cited by

0References

15Claims

0Family size

Assignee

University of Massachusetts · US

Inventors

Guangping Gao · Rosemont, US
Dan Wang · Beijing, CN

Key dates

Filing date	Apr 13, 2017
Grant date	Oct 3, 2023
Priority date	—
Expiry date	Oct 21, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2800/80
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The disclosure in some aspects relates to methods and compositions for repairing mutations (e.g., compound heterozygous mutations) that are widely found in patients having certain diseases (e.g., monogenic recessive diseases). In some aspects, the disclosure provides a method for targeted allelic exchange using recombinant gene editing complex.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.