Pharmaceutical compositions comprising (s)-4-(4-(4- (((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrtle and methods of using the

US11779580B2 · kind B2 · utility

Assignee

• CELGENE CORPORATION · US

Inventors

• Anjali Agrawal · Jalan Pedongkelan, US
• Ming J. Chen · Valley Cottage, US
• Shyam B. Karki · Fryeburg, US
• Prajwal Gunwanth Thool · Short Hills, US
• Dora Visky · Flemington, US
• Ruimin Xie · Livingston, US

Key dates

• Filing date: Jan 8, 2020
• Grant date: Oct 10, 2023
• Expiry date: Nov 12, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/36
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions.