Multi-armed polyrotaxane platform for protected nucleic acid delivery

US11779653B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Huan Meng · Kaohsiung, TW
• Melissa J. Spencer · Los Angeles, US
• April D. Pyle · Los Angeles, US
• Courtney S. Young · Los Angeles, US
• Xiangsheng Liu · Los Angeles, US
• Ying Ji · 安丰镇, CN
• Michael Reza Emami · Los Angeles, US

Key dates

• Filing date: Sep 27, 2018
• Grant date: Oct 10, 2023
• Expiry date: Jan 19, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G2650/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.