Process of preparing a PD-1/PD-L1 inhibitor

US11780836B2 · kind B2 · utility

Assignee

• Incyte Corporation · US

Inventors

• Jiacheng Zhou · Shanghai, CN
• Shili Chen · Cheshire, US
• Zhongjiang Jia · Kennett Square, US
• Yi Li · Shanghai, CN
• Qiyan Lin · Newark, US
• Pingli Liu · Wilmington, US
• Yongchun Pan · Wilmington, US
• Timothy P. Martin · Noblesville, US
• Bo Shen · Ward, US
• Chongsheng Eric Shi · Wilmington, US
• Naijing Su · Hockessin, US
• Yongzhong Wu · Chadds Ford, US
• Michael Xia · Wilmington, US

Key dates

• Filing date: Nov 5, 2021
• Grant date: Oct 10, 2023
• Expiry date: Jan 18, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to processes of preparing PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or salts thereof, related synthetic intermediates, and salts of the intermediates, where the PD-1/PD-L1 inhibitor is useful in the treatment of various diseases including infectious diseases and cancer.