Mammalian cells for producing adeno-associated viruses
US11781116B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Feb 17, 2018 |
| Grant date | Oct 10, 2023 |
| Priority date | — |
| Expiry date | May 9, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2999/007
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A mammalian cell comprising at least four distinct recombination target sites (RTS), an adenovirus (Ad) gene comprising E1A, E1B or a combination thereof, and a promoter operatively linked to the Ad gene, wherein the RTS, the Ad gene, and the promoter are chromosomally-integrated; methods for using the cell for generating a recombinant adeno-associated virus (rAAV) producer host cell; and methods for using the AAV producer host cell to produce, package and purify rAAV.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.