Patent · US Active

Enzymatic DNA repair

US11781169B2 · kind B2 · utility

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20Claims

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Assignee

MICROSOFT TECHNOLOGY LICENSING, LLC · US

Inventors

Robert N. Grass · Zürich, CH
Alexander Xavier Christof Kohll · Calmus, LU
Weida Chen · Zürich, CH

Key dates

Filing date	Oct 5, 2018
Grant date	Oct 10, 2023
Priority date	—
Expiry date	Feb 1, 2039

Classification

Technology area (CPC G)Physics
CPC primaryG11C13/0019
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

One or more enzymes are used to repair damage in synthetic DNA molecules that encode digital information. The enzymes are included in a repair mixture containing one or more of DNA polymerase, DNA ligase, T4 Endonuclease, Endonuclease IV, Endonuclease VIII, and uracil glycosylase. The repair mixture may also contain one or more of a buffering solution, oxidized nicotinamide adenine dinucleotide (NAD+), and deoxyribose nucleoside triphosphates (dNTPs). The synthetic DNA molecules are incubated with the repair mixture for approximately four hours. Use of the repair solution allows recovery of the digital information from damaged DNA molecules.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.