Methods of detecting, measuring, or imaging a concentration or location of a therapeutic agent
US11786215B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 2020 |
| Grant date | Oct 17, 2023 |
| Priority date | — |
| Expiry date | Jan 23, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N2007/0039
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Systems and methods for monitoring and controlling delivery of a therapeutic compound to a brain of a subject using FUS-BBBD are disclosed. The method includes treating the brain of the subject with focused ultrasound in combination with microbubbles for blood-brain barrier disruption (FUS-BBBD), administering the therapeutic agent to the subject; and obtaining a map of a concentration of the therapeutic agent delivered to the brain of the subject using passive cavitation imaging (PCI). The delivery of focused sound may be modulated to match the map of the concentration of the therapeutic agent delivered to the brain of the subject to a desired spatial distribution of the therapeutic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.