Low benzalkonium chloride bimatoprost ophthalmic compositions with effective penetration and preservation properties
US11786538B2 · kind B2 · utility
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18References
20Claims
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Key dates
| Filing date | Dec 8, 2020 |
| Grant date | Oct 17, 2023 |
| Priority date | — |
| Expiry date | Dec 8, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/44
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to ophthalmic compositions comprising from 0.005% to 0.02% bimatoprost by weight, less than 100 ppm benzalkonium chloride, and a secondary penetration enhancer that detectably enhances penetration of bimatoprost into a mammalian eye such that elevated intraocular pressure is effectively reduced to an extent statistically comparable to compositions comprising higher amounts of bimatoprost and benzalkonium chloride. Further, the invention also provides a process of preparing such compositions and methods of their use for lowering intraocular pressure and treating glaucoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.