Chimeric cytokine receptors bearing a PD-1 ectodomain
US11786553B2 · kind B2 · utility
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33Claims
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Key dates
| Filing date | Feb 28, 2020 |
| Grant date | Oct 17, 2023 |
| Priority date | — |
| Expiry date | Sep 18, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are PD-1 chimeric cytokine receptors. When present on chimeric antigen receptor (CAR)-bearing immune cells, such receptors allow for increased immune cell activation, proliferation, persistence, and/or potency, when engaged with PD-1 ligands or activation with an anti-PD-1 antibody. Also provided are methods of making and using the chimeric cytokine receptors described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.