Systems and methods including a rotary valve for at least one of sample preparation or sample analysis

US11786898B2 · kind B2 · utility

Assignee

• Illumina, Inc. · US

Inventors

• Sebastian Bohm · San Diego, US
• Alex Aravanis · San Francisco, US
• Alexander Hsiao · Los Angeles, US
• Behnam Javanmardi · San Francisco, US
• Tarun Khurana · San Diego, US
• Hai Quang Tran · San Diego, US
• Majid Aghababazadeh · Cupertino, US
• M. Shane Bowen · Encinitas, US
• Boyan Boyanov · Portland, US
• Dale Buermann · San Diego, US

Key dates

• Filing date: Mar 13, 2020
• Grant date: Oct 17, 2023
• Expiry date: Oct 17, 2041

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F16K2099/0084
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.