Carboxylic diarythiazepineamines as mixed mu- and delta-opioid receptor agonists

US11787772B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Andrew Carry Kruegel · New York, US
• Dalibor Sames · New York, US
• Jonathan A. Javitch · Dobbs Ferry, US

Key dates

• Filing date: Mar 15, 2018
• Grant date: Oct 17, 2023
• Expiry date: Jul 29, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with a pain, a depressive disorder, a mood disorder, an anxiety disorder, borderline personality disorder, opioid addiction, or opioid withdrawal symptoms by administering the compound to the subject.