Patent · US Active

Pyrazolopyridine derivatives and uses thereof

US11787785B2 · kind B2 · utility

0Cited by

3References

15Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Simone BONAZZI · Cambridge, US
Artiom CERNIJENKO · Cambridge, US
Jennifer Stroka Cobb · Stow, US
Natalie Dales · Arlington, US
Janetta Dewhurst · Framingham, US
Matthew James HESSE · Oakland, US
Rama Jain · Danville, US
John Ryan Kerrigan · Wakefield, US
Hasnain Ahmed Malik · Boston, US
James R. MANNING · Pleasant Hill, US
Gary O'Brien · Maynard, US
Andrew W. Patterson · Somerville, US
Noel Marie-France Thomsen · Cambridge, US
Pamela YF TING · Somerville, US

Key dates

Filing date	Mar 14, 2022
Grant date	Oct 17, 2023
Priority date	—
Expiry date	Mar 14, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.