Aryl piperidines as monoacylglycerol lipase modulators

US11787798B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Michael K. Ameriks · San Diego, US
• Cynthia B. Berry · Poway, US
• Krisztián Biró · Budapest, HU
• Pablo Garcia-Reynaga · San Diego, US
• Andrew V. Samant · San Diego, US
• Warren Wade · San Diego, US

Key dates

• Filing date: Mar 25, 2021
• Grant date: Oct 17, 2023
• Expiry date: May 5, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/0812
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Aryl piperidine compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: wherein X, R2a, R2b, R3, R4, R5a and R5b are as defined herein.