Multi-specific antibodies and methods of making and using thereof

US11787863B2 · kind B2 · utility

Assignees

• SystImmune, Inc. · US
• BAILI-BIO (CHENGDU) PHARMACEUTICAL CO., LTD. · CN

Inventors

• Yi Zhu · Chengdu, CN
• Ole Olsen · Everett, US
• Dong Xia · Redmond, US
• David Jellyman · Duvall, US
• Katrina Bykova · Seattle, US
• Anne-Marie K. Rousseau · Seattle, US
• Bill Brady · Watertown, US
• Blair R. Renshaw · Renton, US
• Brian R. Kovacevich · Snohomish, US
• Yu Liang · Tokyo, JP
• Zeren Gao · Redmond, US

Key dates

• Filing date: Jun 22, 2018
• Grant date: Oct 17, 2023
• Expiry date: Mar 29, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.