Recombinant microorganisms and uses therefor
US11788092B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Feb 7, 2022 |
| Grant date | Oct 17, 2023 |
| Priority date | — |
| Expiry date | Apr 9, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y604/01002
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Microorganisms are genetically engineered to produce 3-hydroxypropionate (3-HP). The microorganisms are carboxydotrophic acetogens. The microorganisms produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO2. A β-alanine pyruvate aminotransferase from a microorganism that contains such an enzyme is introduced. Additionally, an acetyl-coA carboxylase may also be introduced. The production of 3-HP can be improved. This can be effected by improved promoters or higher copy number or enzymes that are catalytically more efficient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.