Patent · US Active

Car-t cell assay for specificity test of novel antigen binding moieties

US11788205B2 · kind B2 · utility

2Cited by

0References

21Claims

0Family size

Inventors

Christian Klein · Iffeldorf, DE
Ekkehard Moessner · Kreuzlingen, CH
Lydia Jasmin Hanisch · Schlieren, CH
Wei Xu · Saginaw, US
Camille DELON · Oberengstringen, CH
Diana DAROWSKI · Schlieren, CH
Christian Jost · Schlieren, CH
Vesna Pulko · Schlieren, CH

Key dates

Filing date	Jun 19, 2020
Grant date	Oct 17, 2023
Priority date	—
Expiry date	Nov 25, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2740/15043
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T cell) assays to test antigen binding moieties in different formats. Furthermore, the present invention relates to the use of CAR-T cells, transfected/transduced with an engineered chimeric antigen receptor (CAR) comprising a target antigen binding moiety capable of specific binding to a target antigen, e.g., tumor associated antigens.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.