Methods and systems for computer-generated predictive application of neuroimaging and gene expression mapping data
US11791016B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 2, 2018 |
| Grant date | Oct 17, 2023 |
| Priority date | — |
| Expiry date | May 29, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16H30/20
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present disclosure relates to computer generated topographies from computer correlations of neurobehavioral phenotype mapping data and gene expression mapping data. Neurobehavioral phenotype mapping data is obtained for a selected phenotype and correlated with gene expression mapping data for one or more genes to define a phenotype-gene pair topography for each phenotype-gene pair. A score for each phenotype-gene pair is determined based on the correlation. The scores are used to identify genes, or drug targets, associated with the respective gene of the respective phenotype-gene pair. Conversely, gene expression mapping data is obtained for a selected gene and correlated with neurobehavioral phenotype mapping data for one or more phenotypes to define a gene-phenotype topography for each gene-phenotype pair. A score for each gene-phenotype pair is determined based on the correlation. The scores are used to identify a phenotype associated with the respective phenotype-gene pair.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.