Patent · US Active

Anionic nanocomplexes for nucleic acid delivery

US11793756B2 · kind B2 · utility

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16Claims
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Key dates

Filing dateJan 10, 2019
Grant dateOct 24, 2023
Priority date
Expiry dateSep 10, 2039

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61P35/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A non-viral delivery complex comprising a cationic core which is a nanoparticle comprising a peptide having a polycationic nucleic acid binding component, a cleavable spacer element and a cell surface receptor binding component; a nucleic acid and optionally a cationic lipid; and an anionic liposomal coating surrounding the cationic core, said coating comprising lipids from a subject's cells. Also related formulations, uses and methods.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.