Patent · US Active

Pharmaceutical compositions of nilotinib

US11793809B2 · kind B2 · utility

2Cited by

6References

9Claims

0Family size

Assignee

Slayback Pharma LLC · US

Inventors

Paras P. JAIN · Amravati, IN
Ajay Singh · Princeton, US
Keerthi Priya · Ghanpur, IN
Girish Kumar Jain · Ashti, IN
Girish G. Kore · Jamkhed, IN
Sandeep Jain · Milpitas, US
Hanimi Reddy Bapatu · Hyderabad, IN

Key dates

Filing date	Nov 20, 2020
Grant date	Oct 24, 2023
Priority date	—
Expiry date	Aug 17, 2041

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K9/4866
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Amorphous solid dispersions of nilotinib fumarate or nilotinib tartrate are provided, as well as pharmaceutical compositions thereof, wherein the compositions exhibit enhanced bioavailability in the fasted state. Preferably, the compositions may be orally administered to a patient in either the fed or fasted state, with a decrease or elimination of the food effect. Preferably, following oral administration of the pharmaceutical compositions, there is no substantial difference in the pharmacokinetic parameters (e.g., Cmax, AUC0-t and/or AUC0-infinity) of nilotinib, regardless of whether the pharmaceutical compositions are administered to a subject in the fed or fasted state.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.