Methods and compositions for treating celiac disease

US11795213B2 · kind B2 · utility

Assignee

• Beth Israel Deaconess Medical Center, Inc. · US

Inventors

• Detlef Schuppan · Mainz, DE
• Yvonne Junker · Kiel, DE
• Towia Libermann · Newton, US
• Simon T. Dillon · Danvers, US

Key dates

• Filing date: Aug 1, 2017
• Grant date: Oct 24, 2023
• Expiry date: Aug 1, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/8245
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention features the treatment of gastrointestinal disorders associated with an innate immune response triggered by alpha amylase inhibitor CM3, alpha amylase inhibitor 0.19 (0.19), CM1, CM2, CMa, CMd, CM 16, CMb, CMX1/CMX3, CMX2, and/or alpha amylase inhibitor 0.53 (0.53). To this end, the invention features pharmaceutical compositions including neutralizing antibodies to CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53, food products containing reduced levels of CM3, 0.19, CM1, CM2, CMa, CMd, CM1 6, CMb, CMX1/CMX3, CMX2, and/or 0.53 protein, the use of oral TLR4 inhibitors to block the effect of said alpha-amylase inhibitors, assays for identifying CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53 content in food products, and assays for diagnosing subjects with a disorder related to CM3, 0.19, CM1, CM2, CMa, CMd, CM 16, CMb, CMX1/CMX3, CMX2, and/or 0.53 triggered innate immune responses.