Diagnosis and therapy of cancer involving cancer stem cells

US11795218B2 · kind B2 · utility

Assignees

• BioNTech AG · DE
• ASTELLAS PHARMA INC. · JP
• TRON-Translationale Onkologie an der Universitatsm · DE

Inventors

• Ugur Sahin · Mainz, DE
• Ozlem Tureci · Homburg, DE
• Korden Walter · Mainz, DE
• Meike Wagner · Mainz, DE
• Maria Kreuzberg · Mainz, DE
• Sabine Hacker · Mainz, DE
• Stefan Jacobs · Mainz, DE

Key dates

• Filing date: Feb 19, 2020
• Grant date: Oct 24, 2023
• Expiry date: Oct 8, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.