Patent · US Active

Muscle-targeting complex comprising an anti-transferrin receptor antibody linked to an oligonucleotide

US11795233B2 · kind B2 · utility

27Cited by
101References
30Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMar 16, 2023
Grant dateOct 24, 2023
Priority date—
Expiry dateMar 16, 2043

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2310/3513
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DUX4. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.