Ultrathin interfacial layer on a hydrogel to direct its surface properties and cell adhesion
US11795431B2 · kind B2 · utility
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4References
17Claims
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Key dates
| Filing date | Aug 17, 2018 |
| Grant date | Oct 24, 2023 |
| Priority date | — |
| Expiry date | Jul 27, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2539/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method is disclosed for coating and patterning hydrogels in order to modify surface properties. The method exploits the water content of the hydrogel and the hydrophobicity of the reaction solvent to create a thin oxide adhesion layer on the hydrogel surface. This oxide adhesion layer enables rapid transformation of the hydrophilic, cell non-adhesive hydrogel into either a highly hydrophobic or a cell-adhesive hydrogel by reaction with an alkylphosphonic acid or an α,ω-diphosphonoalkane, respectively. Also disclosed are coated, patterned hydrogels and constructs comprising the coated, patterned hydrogels.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.