Derivation of hepatic stem cells and mature liver cell types and uses thereof
US11795436B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 4, 2020 |
| Grant date | Oct 24, 2023 |
| Priority date | — |
| Expiry date | Aug 1, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/42
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application describes liver stem cells (LSC), and differentiated hepatocytes, cholangiocytes, and 3D cellular structures derived therefrom. Methods for producing LSC and mature, differentiated hepatocytes and cholangiocytes in culture are provided. Also provided are cell culture systems and cell culture media for producing a homogenous population of liver stem cells that remain in an undifferentiated state over multiple passages in culture. The LSC and methods are useful for producing homogenous populations of hepatocytes and cholangiocytes for downstream applications. The LSC can be transplanted into subjects to treat liver diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.