Use of tonicifying agents to enhance recombinant adeno-associated virus yield
US11795473B2 · kind B2 · utility
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21References
17Claims
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Key dates
| Filing date | Oct 13, 2017 |
| Grant date | Oct 24, 2023 |
| Priority date | — |
| Expiry date | Sep 6, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14152
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides methods for the production of recombinant adeno-associated virus vectors (rAAV), comprising culturing producer cells in media with increased osmolality. Also provided are methods for decreasing the production of helper virus by a rAAV producer cell, comprising culturing the producer cell in media with increased osmolality.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.