Fungal cell with improved protein production capacity
US11795487B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Jul 30, 2018 |
| Grant date | Oct 24, 2023 |
| Priority date | — |
| Expiry date | Jul 30, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P21/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention related to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing and secreting different recombinant proteins. The improved ability is obtained by disruption in intracellular transport between the Golgi and the endosome. In particular embodiments, the disruption is achieved by downregulation or deletion of the gene encoding a Tda3p homolog. The fungal cell and method of the invention would allow for large-scale production of recombinant proteins in fungal cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.