Detection of biomarkers using plasmonic gratings
US11796473B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 11, 2018 |
| Grant date | Oct 24, 2023 |
| Priority date | — |
| Expiry date | Sep 29, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/6439
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention broadly relates techniques for imaging and medical diagnosis and, more particularly, to the fabrication of flexible plasmonic gratings and the use thereof in detection of biomarkers. A first aspect of the invention provides for techniques for the fabrication of novel, flexible plasmonic gratings that can be inexpensively fabricated onto fiber optic cables, flexible films and substrates with non-uniform surfaces to enhance the imaging resolution. A second aspect of the invention provides for an ultra¬high sensitivity (single molecule counting) biomarker detection platform useable for medical diagnosis based on a fluorescent sandwich ELISA assay performed on a plasmonic grating platform incorporated with a fluorescence detection unit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.