Immobilization strategies for enhancing sensitivity of electrochemical aptamer-based sensors
US11796499B2 · kind B2 · utility
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Key dates
| Filing date | Dec 13, 2022 |
| Grant date | Oct 24, 2023 |
| Priority date | — |
| Expiry date | Dec 13, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5438
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The subject invention provides methods for fabricating electrochemical aptamer-based (E-AB) sensors with enhanced sensitivity, signal-to-noise ratios, LOD, and improved stability and reproducibility. The subject invention also provides methods for aptamer immobilization on the surface of the electrode, which favors sufficient spacing between aptamers at the microscale to achieve optimal target recognition, folding, and signal transduction. The E-AB sensors of the subject invention provide superior sensing regardless of the sequence or structure of the bound aptamers or the physiochemical properties of the target.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.