Structural rectal atlas deformation features for characterizing intra-wall and peri-wall chemoradiation response on magnetic resonance imaging (MRI)

US11798179B2 · kind B2 · utility

Assignee

• CASE WESTERN RESERVE UNIVERSITY · US

Inventors

• Anant Madabhushi · Beachwood, US
• Jacob Antunes · Cincinnati, US
• Zhouping Wei · Cleveland, US
• Pallavi Tiwari · Shaker Heights, US
• Satish Viswanath · Highland Park, US
• Charlems Alvarez Jimenez · Bogota, CO

Key dates

• Filing date: Sep 22, 2021
• Grant date: Oct 24, 2023
• Expiry date: Apr 26, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30096
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present disclosure, in some embodiments, relates to a non-transitory computer-readable medium storing computer-executable instructions. The computer readable medium is configured to cause a processor to access an image volume of a rectum comprising a rectal tumor. A forward mapping is generated based on non-rigidly registering a healthy rectal atlas to the image volume. The forward mapping is inverted to generate an inverse mapping from the image volume to the healthy rectal atlas. Based on the inverse mapping, a plurality of deformation vectors, associated with a deformation within a rectal wall of the rectum, are determined. Magnitude based deformation features and orientation based deformation features are computed from the plurality of deformation vectors. One or more of the magnitude based deformation features and one or more of the orientation based deformation features are utilized to determine a response of a patient to a chemoradiation treatment.