Cyclobutyl amide monoacylglycerol lipase modulators

US11802111B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Jesus Alcazar · Toledo, ES
• Michael K. Ameriks · San Diego, US
• Cynthia B. Berry · Poway, US
• Pablo Garcia-Reynaga · San Diego, US
• Brian Ngo Laforteza · San Diego, US
• Andrew V. Samant · San Diego, US

Key dates

• Filing date: Sep 21, 2021
• Grant date: Oct 31, 2023
• Expiry date: Sep 21, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to depression, major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, and bipolar disorder), cancers and eye conditions: wherein R1, , R3, and L are as defined herein.