Modified L-asparaginase

US11802279B2 · kind B2 · utility

Assignee

• Jazz Pharmaceuticals Ireland Limited · IE

Inventors

• Lars Friedrich · Weinheim, DE
• Anne O'Donnell · Dublin, IE

Key dates

• Filing date: Jun 1, 2021
• Grant date: Oct 31, 2023
• Expiry date: Jun 1, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides a modified protein that is a combination of (i) an L-asparaginase and (ii) one or more (poly)peptide(s), wherein the (poly)peptide consists solely of proline and alanine amino acid residues, and methods of preparation and use thereof.