Patent · US Active

Enzyme for synthesizing hydroxyl acetaldehyde and/or 1,3-dihydroxyacetone by catalyzing formaldehyde, and applications thereof

US11802280B2 · kind B2 · utility

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15Claims

0Family size

Assignee

TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Huifeng Jiang · Tianjin, CN
Xiaoyun Lu · 流花街道, CN
Yuwan Liu · Tianjin, CN
Yiqun Yang · Sacramento, US
Lina Lu · Hangzhou City, CN
Sheng Yang · Shanghai, CN
Junran Gou · Tianjin, CN

Key dates

Filing date	Feb 12, 2018
Grant date	Oct 31, 2023
Priority date	—
Expiry date	Sep 21, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y401/01007
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

An enzyme synthesizes hydroxyl acetaldehyde and/or 1,3-dihydroxyacetone by catalyzing formaldehyde. Site-directed mutation of benzoylformate decarboxylase (BFD) creates a mutant of the enzyme, which can polymerize the formaldehyde, A phosphoketalose (F/XPK) generates acetyl phosphoric acid from the hydroxyl acetaldehyde or 1,3-dihydroxyacetone (DHA). Combination with phosphotransacetylase (Pta) provides a route from the formaldehyde to acetyl coenzyme A in three steps.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.