System and method of magnetic resonance imaging method for monitoring remyelination

US11802927B2 · kind B2 · utility

Assignee

• Cornell University · IT

Inventors

• Reza Rahmanzadeh · Basel, CH
• Cristina Granziera · Binningen, CH
• Yi Wang · New York, US
• Riccardo Galbusera · Freiburg im Breisgau, DE

Key dates

• Filing date: Mar 4, 2022
• Grant date: Oct 31, 2023
• Expiry date: Mar 4, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/5608
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Quantitative susceptibility mapping methods, systems and computer-accessible medium include generating images of tissue magnetism property from complex magnetic resonance imaging data using the Bayesian inference approach. The tissue magnetism images is then used to monitor remyelination, such as remyelination in multiple sclerosis patients in response to therapy. Multiple sclerosis lesions defined on magnetic resonance imaging are further characterized on tissue magnetism images into hyperintense, isointense and hypointense parts for measuring remyelination. Thus, magnetic susceptibility information and other tissue properties associated with at least one structure are determined.