Process of making abaloparatide
US11806387B1 · kind B1 · utility
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28Claims
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Key dates
| Filing date | May 19, 2023 |
| Grant date | Nov 7, 2023 |
| Priority date | — |
| Expiry date | May 19, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/084
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein is an improved process for preparing abaloparatide. The process generally utilizes solid phase peptide synthesis employing an Fmoc-protection scheme. Incorporating a systematic recoupling step of a glutamine residue (Gln16) has been found to minimize the formation of an undesirable des-Gln16 abaloparatide impurity, which is often obtained in significant quantities in the conventional process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.