Patent · US Active

Selection vectors and methods of selecting eukaryotic host cells

US11807855B2 · kind B2 · utility

0Cited by

14References

6Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Yehuda G. Assaraf · Rakefet, IL
Thomas Jostock · Neuenburg am Rhein, DE
Hans-Peter Knopf · Schallstadt, DE

Key dates

Filing date	Jul 29, 2014
Grant date	Nov 7, 2023
Priority date	—
Expiry date	Jul 29, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2800/40
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The disclosure is directed to an expression vector or a combination of at least two expression vectors for producing a polypeptide of interest, the vector or vectors comprising a polynucleotide encoding a mutated folate receptor as a selectable marker. The disclosure also relates to host cells, selection methods and methods for producing polypeptides with high yield.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.