Recombinant influenza viruses with stabilized HA for replication in eggs

US11807872B2 · kind B2 · utility

Assignees

• Wisconsin Alumni Research Foundation · US
• THE UNIVERSITY OF TOKYO · JP

Inventors

• Yoshihiro Kawaoka · Middleton, US
• Shinya Yamada · Kyoto, JP
• Shiho Chiba · Madison, US

Key dates

• Filing date: Aug 27, 2020
• Grant date: Nov 7, 2023
• Expiry date: Aug 27, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16151
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation or decrease the need for HA binding to cells.