Genetically engineered foot and mouth disease virus and related proteins, polynucleotides, compositions, methods and systems

US11813320B2 · kind B2 · utility

Assignees

• Lawrence Livermore National Security, LLC · US
• THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF AGRICULTURE · US
• UNIVERSITY OF CONNECTICUT · US

Inventors

• Aida Elizabeth Rieder · Westbrook, US
• Teresa B. De Los Santos · Miller Place, US
• Luis Leandro Rodriguez · Niantic, US
• Devendra Rai · Old Saybrook, US
• Fayna C. Diaz-San Segundo · Lakeland, US
• Paul D. Hoeprich, Jr. · Pleasanton, US

Key dates

• Filing date: Feb 16, 2021
• Grant date: Nov 14, 2023
• Expiry date: Aug 11, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/32162
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.