Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response
US11813352B2 · kind B2 · utility
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30Claims
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Key dates
| Filing date | Nov 20, 2018 |
| Grant date | Nov 14, 2023 |
| Priority date | — |
| Expiry date | Oct 8, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition comprising a glucose-responsive charge-switchable polymer is described. In the absence of glucose or under normoglycemic conditions, the positively charged polymer can be complexed with negatively charged therapeutic agents, such as insulin. Under hyperglycemic conditions, the positive charge of the polymer is reduced, and the polymer/therapeutic agent complex can disassemble, allowing the therapeutic agent to be released. Pharmaceutical compositions, nanoparticles, and microneedle arrays of the polymer and/or polymer/therapeutic agent complex and methods of treating diabetes are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.