Pyridine N-oxide derivatives useful as factor XIa inhibitors

US11814364B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Guozhang Xu · King of Prussia, US
• Boying Guo · Glenside, US
• Zhijie Liu · Harleysville, US
• Jing Zhang · Wantage, US
• Micheal Gaul · Yardley, US
• Eugene B. Grant · Flemington, US
• Mark J. Macielag · Spring House, US
• Tianbao Lu · Collegeville, US
• Tho V. Thieu · Ambler, US

Key dates

• Filing date: Mar 17, 2022
• Grant date: Nov 14, 2023
• Expiry date: Mar 17, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.