Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof
US11814367B2 · kind B2 · utility
3Cited by
12References
41Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 14, 2022 |
| Grant date | Nov 14, 2023 |
| Priority date | — |
| Expiry date | Mar 14, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided herein are compounds of formula (I′): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y2, Y3, L1, L2, X1, X2, X3, X4, X5, Q1, R1, R2, Rk, Rm, and Rn are as defined elsewhere herein. Also provided herein are methods of preparing compounds of formula (I′). Also provided herein are methods of inhibiting GYS1 and methods of treating a GYS1-mediated disease, disorder, or condition in an individual in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.