Methods and compounds for restoring mutant p53 function
US11814373B2 · kind B2 · utility
1Cited by
8References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 22, 2020 |
| Grant date | Nov 14, 2023 |
| Priority date | — |
| Expiry date | Nov 21, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.