Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors

US11814380B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Juergen Ramharter · Wien, AT
• Christiane Kofink · Perchtoldsdorf, AT
• Heinz Stadtmueller · Wien, AT
• Tobias Wunberg · Mödling, AT
• Marco Hofmann · Wien, AT
• Anke Baum · Alland, AT
• Michael GMACHL · Wien, AT
• Dorothea RUDOLPH · Wien, AT
• Fabio SAVARESE · Mödling, AT
• Markus Ostermeier · Biberach an der Riß, DE
• Markus Frank · Baden-Baden, DE
• Annika Gille · Ulm, DE
• Stefan Goepper · Bad Herrenalb, DE
• Marco Santagostino · Magenta, IT
• Julian Wippich · Ingelheim am Rhein, DE

Key dates

• Filing date: Sep 24, 2020
• Grant date: Nov 14, 2023
• Expiry date: Sep 24, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention encompasses compounds of formula (1) wherein the groups R1 to R4, A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.