Fc-receptor based affinity chromatography

US11814409B2 · kind B2 · utility

Inventors

• Roberto Falkenstein · Munich, DE
• Hubert Hertenberger · Weilheim, DE
• Petra Rueger · Penzberg, DE
• Tilman Schlothauer

Key dates

• Filing date: Jan 25, 2019
• Grant date: Nov 14, 2023
• Expiry date: Jun 15, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Herein is reported the use of an immobilized non-covalent complex of a neonatal Fc receptor (FcRn) and beta-2-microglobulin (b2m) as affinity chromatography ligand in general and, for example, for the determination of the in vivo half-live of an antibody by determining the ratio of the retention times of the antibody and a reference antibody.